Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine produced by a variety of cell types, including T cells, bone marrow mononuclear lineage, fibroblasts, liver, heart, and melanoma. LIF promotes the long-term maintenance of embryonic stem cells by inhibiting spontaneous differentiation. Other activities include stimulating the acute-phase protein synthesis in hepatocytes, stimulating the differentiation of cholinergic neurons, and inhibiting lipogenesis in adipocytes by inhibiting lipoprotein lipase. Although human LIF is active on mouse cells and is widely used to maintain mouse ESCs to prevent spontaneous differentiation, mouse LIF is not active on human cells because it cannot bind to the human LIF receptor.
This recombinant human LIF is provided in the form of a lyophilized powder, with high activity, high purity, low endotoxin, and without any additional tags.
