Description
Product description
Caerulein is a decapeptide and an agonist of cholecystokinin (CCK) receptor. As a cholecystokinin analog, it can stimulate gastric, bile duct and pancreatic secretion, acting on pancreatic alveolar cells, leading to the secretion of large amounts of digestive enzymes and pancreatic juice, leading to acute edematous pancreatitis. Caerulein can be used to study signal transduction pathways mediated by NF-κB upregulated proteins such as intercellular adhesion molecule (ICAM-1), inflammation-related factors such as NADPH oxidase and Janus kinase. Cerulein can also be used to test gallbladder function and prevent gallbladder pain, renal colic and intermittent claudication pain. It is generally considered an antagonist of endogenous orphins and can be used in conjunction with LPS to establish animal models of pancreatitis. Cerulein has been successfully used to establish acute pancreatitis (AP) models in rats, mice, dogs, Syrian hamsters and other animals. The modeling mechanism is as follows:
1.Upregulate the expression of intercellular adhesion molecule (ICAM-1) in pancreatic acinar cells by stimulating intracellular NF-KB. Surface ICAM-1 in turn promotes neutrophil adhesion to acinar cells thereby enhancing pancreatic inflammatory effects;
2.Induction of pancreatic inflammation by disrupting digestive enzyme secretion and causing cytoplasmic vacuolization and acinar cell death, leading to pancreatic edema;
3.Activate inflammation-promoting factors.
Specifications
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English Synonym
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Caerulein Sulfated; Cerulein, Ceruletide; [Tyr(SO3H)4]Caerulein
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CAS NO.
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17650-98-5
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Formula
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C58H73N13O21S2
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Molecular Weight
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1352.4
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Appearance
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White powder
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Purity
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≥97%
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Solubility
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Soluble in DMSO, insoluble in water
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Sequence
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pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2
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Components
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Components No.
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C331603E
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Size
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1 mg
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Storage
Dry ice shipping. Powder: -85℃~-65℃, valid for 2 years; -15℃~-25℃, valid for 1 year.Solution should be stored at -85°C to -65°C with a shelf life of 6 months; or at -15°C to -25°C with a shelf life of 1 month. Keep refrigerated and dry, avoiding repeated freeze-thaw cycles.
